Previous studies have indicated that in patients with a chronic illness, good adherence to medication, or even to placebo, is more likely to lead to better health and improved survival The incidence of RA and OA in our study, based on physician diagnoses, is higher compared with previous studies Mild muscle pains are one of the frequent side effects of statins documented in 5% to 10% of outpatients on statins In conclusion, this study showed that persistence with statin treatment was associated with an ongoing decrement in the risk for contracting RA.

The product of this reaction, mevalonate, is converted to isoprenyl intermediates that are essential for posttranslational modification of numerous proteins with diverse functions, such as cytoskeletal integrity, protein trafficking, and cellular signaling The effect of statin use on the risk of RA was investigated in 3 previously reported studies In another study from a health maintenance organization cohort, high persistence with statin treatment (PDC ≥80%) was associated with a substantial decrease in the risk of RA (HR 0.58 [95% CI 0.52–0.65]) in comparison to low persistence (PDC <20%) Finally, a case–control study showed an increased risk of RA with statin use (OR 1.71 [95% CI 1.16–2.53]) In 2 observational studies from the UK, the overall unintended effects of statin use were investigated in large population‐based cohorts We analyzed a cohort of more than half a million new statin users from a large population‐based primary care database, with data on exposure and covariates collected prospectively and independently of the outcome measure, in a real‐life setting.

After adjustment for potential confounders, highly persistent patients had a hazard ratio of 0.58 (95% confidence interval 0.52–0.65) for RA compared with nonpersistent patients. Previous studies have indicated that in patients with a chronic illness, good adherence to medication, or even to placebo, is more likely to lead to better health and improved survival The incidence of RA and OA in our study, based on physician diagnoses, is higher compared with previous studies Mild muscle pains are one of the frequent side effects of statins documented in 5% to 10% of outpatients on statins In conclusion, this study showed that persistence with statin treatment was associated with an ongoing decrement in the risk for contracting RA.

The researchers then analyzed the incidence of newly diagnosed rheumatoid arthritis, recording the date of first diagnostic codes (International Classification of Diseases, 9th revision [ICD-9]) associated with rheumatoid arthritis during the study follow-up period. Medicines and Healthcare Products Regulatory Agency (# 14_051) and the Ethics Committee of Jewish General Hospital, (# 14‐053). We randomly selected 10 controls from each risk set, and each control was assigned the index date that resulted in a follow‐up duration equal to that of the corresponding case. During the study follow-up period, there were 2,578 incident cases of rheumatoid arthritis and 17,878 incident cases of osteoarthritis.

5 Following 6 months of treatment, the intervention group showed significant improvement in levels of intercellular adhesion molecule 1 and fibrinogen. The beneficial effects of statins in rheumatoid arthritis (RA) have been suggested previously, but it is unclear whether statins may prevent its development.

Our case selection algorithm required that multiple cumulative qualifiers be fulfilled over time whereas the earliest of those qualifiers was assigned as the index date, i.e., our index dates were earlier in time than dates of case ascertainment in the primary analysis. The dose varies depending on your body weight and the condition being treated.
In the OA analysis, a 10% increase in PDC was related with an adjusted HR of 0.99 (95% CI 0.99–1.00) for OA. As a result, controls were matched to cases with respect to sex, age at index date (within 5 years), calendar year of cohort entry (within 1 year), and follow‐up duration from statin initiation.

Our free recipe guide shows you the best foods to fight inflammation. The crude incidence density rate of rheumatoid arthritis among patients who did not persistently take statins was 51% higher than that of patients who used statins for at least 80% of the follow-up period.


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