In The Hub is a platform to share ideas, cases and concepts that bridge the gap between academia and the real world. Moreover, these effects were shown in just 12 weeks of treatment.However, the discrepancy between non-significant MADRS scores but significant changes in quality of life and functioning is interesting yet puzzling.It is possible that minocycline has other unknown effects on the body, which warrants further research into minocycline’s mechanism of action on depressive Quality of life and functioning were measured using clinician-rated (CGI-I and LIFE-RIFT) and patient-rated (PGI and Q-LES-Q) scales.
N-acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis.4. Minocycline is already approved for use in humans (long-term treatment of acne) and is inexpensive in comparison to other antidepressant drugs.Furthermore, in another study, a minocycline adjunct allowed lower doses of antidepressants to be used, meaning that long-term adjunctive therapy may be a way to use lower doses of antidepressants and thereby reduce side-effects. Secondary outcomes included the Clinical Global Impression–Improvement (CGI-I), Clinical Global Impression-Severity (CGI-S), Patient Global Impression (PGI), Hamilton Anxiety Rating Scale (HAM-A).Quality of life of patients during the length of the trial was assessed using the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social and Occupational Functioning Scale (SOFAS) and the Range of Impaired Functioning Tool (LIFE-RIFT).Primary and secondary outcomes were analysed using mixed models, repeated measures (MMRM) analysis of covariance (ANOVA) split-plot in time and this was based on all patients having being tested at least once.At baseline, the patient cohorts were shown to have moderate to severe depression with a MADRS score of 31.7 (+/- 4.0) in the placebo group and 31.0 (+/- 4.6) in the minocycline group.Depression was also shown to be chronic across all 71 patients with a mean duration of 14 years, and co-morbid anxiety was evident in 42% of patients.This is the first randomised controlled trial that has studied adjunctive minocycline therapy for moderate-severe depression.
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