Gardner J. Epub 2015 Nov 4.Int Urol Nephrol. Aims: The primary objective was to investigate the efficacy of desmopressin orally disintegrating tablet versus placebo in patients with nocturia. Epub 2014 Mar 5. (1,2) Recently, a new brand of desmopressin sublingual tablet (lyophilisate-an orally disintegrating tablet; Noqdirna-Ferring) has been licensed for use in adults of any age for the treatment of nocturia due to idiopathic nocturnal polyuria. Desmopressin has been used for many years in the treatment of diabetes insipidus, nocturnal enuresis (involuntary urination while asleep) and nocturia associated with multiple sclerosis (in adults aged up to 65 years); it has also been recommended in certain circumstances for the treatment of nocturia in men and women (previously, an unlicensed use). It is common in older men. Beneficial effects of desmopressin on nocturia were maintained and increased in patients completing 10 or 12 months of further treatment in a nonblind extension of short-term trials. Desmopressin has been used for many years in the treatment of diabetes insipidus, nocturnal enuresis (involuntary urination while asleep) and nocturia associated with multiple sclerosis (in adults aged up to 65 years); it has also been recommended in certain circumstances for the treatment of nocturia in men and women (previously, an unlicensed use). Also known as: DDAVP, Nocdurna, DDAVP Nasal, DDAVP Rhinal Tube, Stimate, Minirin, Noctiva The following information is NOT intended to endorse any particular medication. The initial starting dose should be 50 to 100 mcg, with lower dosing for the advanced older patient. In two large, randomised, double-blind phase III trials in adults with nocturia associated with nocturnal polyuria, 3 weeks of oral desmopressin therapy was significantly more effective than placebo in reducing the mean number of nocturnal voids and in normalising the rate of nocturnal urine production. Results. The formulation of the rapidly dissolving tablets and sex-specific dosing was effectively demonstrated in reducing nighttime bathroom trips.“Millions of individuals across the country face nocturia each night, many of whom suffer the daytime consequences of fatigue and lost productivity,” Jeffrey Weiss, MD, FACS, professor, chairman of urology, State University of New York Downstate Medical Center, said in a In clinical trials 1 and 2, the co-primary endpoints included the change in number of nighttime voids compared to baseline and the percentage of patients who achieved at least a 33% reduction from baseline in the mean number of nighttime voids during 3 months of treatment.The trials demonstrated an average reduction of nocturnal voids of 52% in women (n=102) and 43% in men (n=102), relative to the mean baseline (2.9 for women and 3 for men) with a reduction of 1.5 and 1.3, respectively.Additionally, 78% of women and 67% of men receiving NOCDURNA achieved a 33% reduction in mean number of voids throughout a 3-month period when compared to baseline.Common adverse effects with an incidence greater than 2% included dry mouth, dizziness and hyponatremia, however, NOCDURNA was approved with a boxed warning because of its possibility to cause hyponatremia.NOCDURNA acts on receptors in the kidney in order to absorb additional fluid and produce less urine during the night.The treatment will be made available in the US in the second half of 2018. 2015 Nov-Dec;9(11-12):E770-4. Pharmacodynamics, safety and patient-reported quality of life (QoL) outcomes were also evaluated. Epub 2013 Feb 20.van Kerrebroeck P, Rezapour M, Cortesse A, Thüroff J, Riis A, Nørgaard JP.Eur Urol. It is also used to treat nocturia. 2007 Jul;52(1):221-9. doi: 10.1016/j.eururo.2007.01.027. The US Food and Drug Administration (FDA) approved desmopressin acetate (NOCDURNA), the first sublingual tablet for treatment of nocturia due to nocturnal polyuria in adults who awaken at least 2 times per night to urinate, announced Ferring Pharmaceuticals. Radke T, A systematic review by Ebell et al. Compared with vasopressin, desmopressin has a longer lasting and more potent antidiuretic effect and is devoid of vasopressor and uterotonic effects. Desmopressin, a synthetic antidiuretic hormone analogue, is the only drug currently approved for the treatment of nocturia associated with nocturnal polyuria or multiple sclerosis (MS). Quality was assessed using the standard Cochrane Collaboration bias risk guidelines. doi: 10.1002/14651858.CD012059.pub2.Neurourol Urodyn. Desmopressin, a synthetic antidiuretic hormone analogue, is the only drug currently approved for the treatment of nocturia associated with nocturnal polyuria or multiple sclerosis (MS). Outcomes were stratified by dose (less than 100 mcg vs. 100 mcg or greater).Overall, patients receiving desmopressin experienced a significant decrease in the number of nocturnal voids compared with those taking placebo (0.5 fewer voids; 95% confidence interval, 0.35 to 0.65). This review will look at the pharmacology of desmopressin and will review the evidence in th e literature that would support its use in nocturia. Two multinational, multicentre trials were conducted, one in men and the other in women, each following the same protocol. Headaches and hyponatremia were the most commonly reported adverse effects; complications and severe adverse events were rare.
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