0000006107 00000 n Blood pressure is only a predictor of cardiovascular risk. Furthermore, office BP values had returned to pretreatment levels in both groups during the washout. Despite these beliefs, there is some suggestion that cardiovascular outcomes are not necessarily the same with these 2 drugs. equivalent to chlorthalidone 12.5 mg TABLE 2 Effect of different diuretic doses on systolic blood pressure Diuretic and dose Study Mean difference in SBP vs placebo (mm Hg) Hydrochlorothiazide 12.5 mg Pool et al, 199714 –4.40 Pool et al, 200715 –5.20 Horie et al, 200716 –7.80 Chrysant, 199417 –7.00 Lacourcière and Arnott, 199418 –10.2 The fixed effects in the model were drug order (chlorthalidone–HCTZ or HCTZ–chlorthalidone), drug, and time. 0000005146 00000 n Of note, the final 24-hour results for chlorthalidone were performed 12 weeks after the last dose of HCTZ (4 weeks of washout followed by 8 weeks of chlorthalidone), which should have reduced the possibility of carryover. Abstract—Hydrochlorothiazide (HCTZ) has often been contrasted with chlorthalidone, but relatively little is known about HCTZ versus indapamide (INDAP). 0000023134 00000 n trailer 0000004107 00000 n 0000020077 00000 n 0000018580 00000 n This systematic review retrieved 9765 publications, and from these, it identified 14 randomized trials with 883 patients comparing HCTZ with INDAP and chlorthalidone on antihypertensive potency The doses of HCTZ and chlorthalidone that were selected for the study were based on our previous review of the literature, which suggested 25 mg of chlorthalidone would be approximately equivalent to 50 mg of HCTZ. 0000014295 00000 n This site uses cookies. Repeated-measures analysis was used to examine changes in potassium between the groups.For mean comparisons involving multiple tests (ie, between drug comparison of office BP change at weeks 2, 4, 6, and 8), Bonferroni’s method was used to adjust the All of the statistical analyses were performed using SAS version 9.1 (SAS Institute, Inc). In the Heart Outcomes Prevention Evaluation trial, ramipril-treated patients had significantly reduced cardiovascular morbidity and mortality compared with those not receiving ramipril.Our ABPM findings suggest the intriguing prospect that a difference in cardiovascular outcomes is possible between chlorthalidone and HCTZ. 0000014916 00000 n Chlorthalidone Side Effects by Likelihood and Severity COMMON side effects. 0000058373 00000 n E-mail © American Heart Association, Inc. All rights reserved. However, on review of these articles, it is interesting to note that several trials reporting neutral or negative results in the diuretic groups often included HCTZ,Some experts have begun to speculate whether there are true differences between HCTZ and chlorthalidone. All of the study medications were broken in half by the study investigators before dispensing to the patient, and patients were instructed to take 1 of the half tablets each morning immediately after arising for the day. Likewise, we did not study doses of HCTZ >50 mg/day or 25 mg/day of chlorthalidone, because their additional antihypertensive effects are questionable and may pose an unnecessary increased risk of hypokalemia.Fourth, our design was single-blind, which could be criticized as allowing bias to occur. The model also included all 2-factor interactions and the 3-factor interaction. One person did not meet inclusion criteria after the baseline ABPM was performed and was subsequently dropped from the study. There are significant pharmacokinetic and pharmacodynamic differences between these diuretics. A number of drugs like diuretics, antidepressants, antipsychotics and antiepileptic drugs can cause lowering of sodium level or hyponatremia as a side effect. 0000009766 00000 n It is known that pharmacokinetic parameters differ at steady state, especially in the elderly, in patients with renal insufficiency, or with drug-drug interactions.Sources continue to list the half-life of HCTZ as short as 2.5 hours.The half-life of HCTZ would suggest that the drug should be given twice daily. Unauthorized The main outcome, 24-hour ambulatory blood pressure (BP) monitoring, was assessed at baseline and week 8, along with standard office BP readings every 2 weeks. 0000022696 00000 n 0000043466 00000 n

Alpha-2 Agonist Drugs Zyloprim, Ayr Saline Nasal Gel For Nosebleeds Effexor Xr, Anthelmintic Drugs Ppt Medicinal Chemistry Lanoxin, Nevirapine Wiki Phenergan, Oracea Generic Wellbutrin Sr, Sperm Count Increase Tablets Cytoxan,

Leave a Reply