During the COVID-19 pandemic, which has had a substantial impact on patients with neurological disease, as well as providing significant challenges to healthcare providers, we hope our journal provides reason for optimism by highlighting recent conceptual and practical clinical advances. Vitamin D is a neurosteroid hormone that regulates neurotransmitters and neurotrophins. Vitamin D may be involved in neuroprotection, control of proinflammatory cytokine induced cognitive dysfunction and synthesis of calcium-binding proteins and … […] It is thought to confer protection against glutamate excitotoxicity by acting on glutamate receptors.

Miss Uzma Taimuri, Miss SA Basnan, Miss W K A Orabi, Miss A Awadallah, Miss F Almowald, and A Hazazi substantially contributed to conception and design of the work. All scores were assessed while patients were on concurrent standard therapy, namely levodopa. Hypovitaminosis D has even been associated with subjective cognitive complaint, an early predictor of MNDs and AD.In addition to genetic impacts of vitamin D/VDR, vitamin D also acts via the membrane-associated rapid response steroid-binding receptor (MARRS). z o.o. Cross-sectional and case-control studies confirm that vitamin D concentrations are lower in individuals with cognitive impairment and dementia although reverse causality remains a possibility. All authors read and approved the manuscript.Copyright © 2020 Sadia Sultan et al. Table 1. Although vitamin D may be considered as a modifiable risk factor, the causal relationship between vitamin D deficiency and CI so far remains inconclusive.The authors declare that they have no conflicts of interest.Dr. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. Moreover, a meta-analysis on vitamin D levels and specific cognitive domains have suggested a strong association between low vitamin D and a range of executive dysfunction, such as impaired processing speed, mental shifting, and information updating.

century. Rats born to vitamin D3-deficient mothers demonstrated a reduction in the nerve growth factor and glial-derived neurotrophic factor compared to control rats [The association of low vitamin D and global cognitive deficit is established through many cross-sectional and longitudinal studies. S. Sultan, MD, substantially contributed to conception or design of the work, finally approved the version to be published, and was responsible for agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Taken together, this body of evidence suggests that vitamin D may be a new paradigm for therapy in the prevention and treatment of dementia and AD.

To get medical coverage for a vitamin D level, use code 268.9 (vitamin D deficiency). Emerging evidence suggests its role in the reduction of Alzheimer’s disease hallmarks such as amyloid-beta and phosphorylated tau. Any author submitting a COVID-19 paper should notify us at MSE: Mini-Mental Status Examination, WFT: word fluency test, DSST: digit symbol substitution test, DWRT: delayed word recall test, and TMT: trial making test; MCI: mild cognitive impairment and RAVLT: Rey auditory verbal learning test; Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), California Verbal Learning Test Second Edition (CVLT-II), verbal fluency and trail making test-B (TMT-B), delayed free recall (DFR), digit span forward and backward tests (DS-F and DS-B), Benton Visual Retention Test (BVRT), animal fluency test (AF), Brief Test of Attention (BTA), and Clock Drawing Test (CDT).Summary of cross-sectional and longitudinal studies depicting association between serum 25(OH)D, cognitive impairment, and Alzheimer’s disease and other dementia.NINCDS-ADRDA: National Institute Neurological and Communicative Disorders and Stroke-Alzheimer Disease and Related Disorders Association, ICD-10: International Classification of Disease, DSM4: Diagnostic and Statistical Manual for Mental Diseases, CDR: clinical dementia rating, MCI: mild cognitive impairment, MMSE: Mini-Mental Status Examination, TMT: trial making test, CI: cognitive impairment, AD: Alzheimer’s disease, and DST: digit symbol test.Overview of systematic reviews with or without meta-analysis depicting the association of serum 25(OH)D with cognitive impairment and Alzheimer’s disease and other dementia.Summary of findings of vitamin D supplementation and its effect on cognition.Low Vitamin D and Its Association with Cognitive Impairment and DementiaCollege of Applied Medical Sciences, Umm Al-Qura University, Abdiya, Makkah, Saudi Arabia Alzheimer's Disease & Dementia

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