pantoprazole (Protonix) rabeprazole (Aciphex) esomeprazole (Nexium) dexlansoprazole (Dexilant) This is the latest in a series of articles that have questioned the safety of these powerful, widely used medications. The pH electrode was passed transnasally into the stomach and positioned 10 cm below the manometrically defined LOS. In the 1980s there were concerns that, by profoundly decreasing stomach acid … The route of administration is also important, particularly for ICU patients. It contains a medicine called esomeprazole which belongs to a group of medicines with the medical term of – proton pump inhibitors. 1, 2 Others have shown little difference in bioavailability and pharmacokinetics when assessed on the 7th day of dosing.



Patients being treated for upper gastrointestinal haemorrhage may be able to take oral medication, but many ICU patients can take medications only intravenously or Subjects in this study were not fasted, and the effect of food ingestion on gastric pH is evident in the mean pH curves, with pH rises occurring at 3, 6 and 12 h after the start of the recordings (Supported by an unrestricted grant from AstraZeneca Canada Inc, Mississauga, ON, Canada.Please check your email for instructions on resetting your password.
Some comparisons of pantoprazole sodium with esomeprazole in health and disease have shown a slight superiority in favour of esomeprazole with regard to raising intragastric pH.The authors attribute this late effect to the unique pharmacokinetics of pantoprazole magnesium. For the study, 274 patients with erosive … The study by Moraes‐Filho et al.
compares a new pantoprazole … Non‐variceal gastrointestinal haemorrhage: guidelinesIntravenous acid suppression – appropriateness of use in a tertiary care settingPrescribing practices and indications for the use of intravenous proton pump inhibitors (IV PPI) in an urban tertiary care centreEsomeprazole improves healing and symptom resolution as compared with omeprazole in reflux esophagitis patients: a randomized controlled trialEsomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitisEfficacy and safety of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomized controlled trialOral and intravenous dosage forms of pantoprazole are equivalent in their ability to suppress gastric acid secretion in patients with gastroesophageal reflux diseaseEffects on 24‐hour intragastric pH: a comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenouslyBioequivalence of esomeprazole 40mg tablet dispersed in water and the intact tablet in male and female healthy volunteersEsomeprazole 40 mg capsules are bioequivalent when administered intact or as the contents mixed with applesauceLong‐term ambulatory gastric pH‐metry: easy to do but difficult to analyzeEsomeprazole 40 mg provides more effective acid control than pantoprazole 40 mgAcid suppression in duodenal ulcer: a meta‐analysis to define optimal dosing with antisecretory drugsThe relationship between suppression of acidity and gastric ulcer healing ratesIs there an optimal degree of acid suppression for healing of duodenal ulcers?Appropriate acid suppression for the management of gastroesophageal reflux diseaseEsomeprazole provides improved acid control vs. omeprazole in patients with symptoms of gastroesophageal reflux diseaseMaximal acid suppression: oral vs. intravenous pantoprazoleInappropriate use of intravenous proton pump inhibitors: Problem extent and cost implicationsInterchangeable Use of Proton Pump Inhibitors Based on Relative Potency, Effective and safe proton pump inhibitor therapy in acid-related diseases – A position paper addressing benefits and potential harms of acid suppression, Gastric Acid-Dependent Diseases: A Twentieth-Century Revolution, Correlates and economic outcomes of proton pump inhibitor use by routes in intensive care unit patients, Expert Review of Pharmacoeconomics & Outcomes Research, Esomeprazole: potent acid suppression in the treatment of acid-related disorders, Clinical trial: Inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects, Oral buffered esomeprazole is superior to i.v. The baseline pH data indicate that all subjects had normal gastric secretory function, unlike some ICU patients in whom gastric acid secretion may be compromised by severe concomitant illness. pantoprazole for rapid rise of intragastric pH: A wireless pH metry analysis, Comparison of the enteral and intravenous lansoprazole pharmacodynamic responses in critically ill patients, Effect of intravenous application of esomeprazole 40?? By continuing to browse this site, you agree to its use of cookies as described in our I have read and accept the Wiley Online Library Terms and Conditions of UseEffect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcersBritish Society of Gastroenterology Endoscopy Committee.

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